Lizard Venom 1
نویسندگان
چکیده
منابع مشابه
Sublethal effects of invasive fire ant venom on a native lizard.
Invasive species can impose novel selection pressures on natives, such as toxins to which native taxa are not adapted. Native species may survive such invasions by evolving mechanisms to avoid toxin exposure or increase toxin tolerance. Red imported fire ants (Solenopsis invicta) employ an alkaloid-based venom to defend their colonies and capture prey. In this study we aim to characterize the s...
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How do proteins evolve novel functions? To address this question, we are studying the evolution of a mammalian toxin, the serine protease BLTX [1], from the salivary glands of the North American shrew Blarina brevicauda. Here, we examine the molecular changes responsible for promoting BLTX toxicity. First, we show that regulatory loops surrounding the BLTX active site have evolved adaptively vi...
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We have purified and characterized the major N-benzoyl-L-arginine ethyl ester hydrolase from the venom of Heloderma horridum horridum. The enzyme belongs to the serine proteinase family, and its activity vs. peptide amide substrates and human high-molecular-weight kininogen suggests a similarity to the family of kallikreins. This interpretation is corroborated by its reactivity with the natural...
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Tyler R. Lyson1, Erik A. Sperling1,†, Alysha M. Heimberg2, Jacques A. Gauthier1, Benjamin L. King3 and Kevin J. Peterson2,* Department of Geology and Geophysics, Yale University, 210 Whitney Avenue, New Haven, CT 06511, USA Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672, USA *Author for corresponde...
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Background: Currently, there are no effective vaccines against leishmaniasis, and treatment using pentavalent antimonial drugs is occasionally effective and often toxic for patients. The PTR1 enzyme, which causes antifolate drug resistance in Leishmania parasites encoded by gene pteridine reductase 1 (ptr1). Since Leishmania lacks pteridine and folate metabolism, it cannot synthesize the pterid...
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ژورنال
عنوان ژورنال: Nature
سال: 1914
ISSN: 0028-0836,1476-4687
DOI: 10.1038/093123a0